Bioaerosols in the lungs of subjects with different ages—Part 2: clearance modeling

摘要: Background: The present contribution deals with theoretical aspects regarding biogenic particle clearance from various lung structures of probands different ages (1, 5, 15, 20 y). With reference to part 1 the study, particles varying in size and shape are subject a detailed analysis. main goal investigation consists an increase our knowledge concerning behaviour bioparticles its dependence upon physiological anatomical factors. Methods: Theoretical was subdivided into four phases, namely fast bronchial clearance, slow alveolar clearance. All these phases were simulated by using well validated stochastic modeling approach, where focus is set on randomly varied mass transfer between compartments human respiratory tract. Whilst effects geometry approximated application projective-diameter concept, age removal process expressed experimentally proven relationship mucus velocities morphometry airway tree. Results: According results simulations efficiency 24-h-retention value, exhibits negative correlation proband's age, whereas other characterized rather conservative among categories. Highest rates may be observed for very fine ( 5 µm) preferentially deposited upper airways, whilst large accumulated alveoli stored there several months years. Conclusions: study comes conclusion that infants children dispose enhanced respect adolescents adults, which faster particulate substances regions. Particles escaping natural filtering airways undergoing deposition identical scenarios groups represent remarkable health hazards.