Effects of quercetin on heart nitric oxide metabolism in l-NAME treated rats.
作者： Valeria Calabró , María C. Litterio , Cesar G. Fraga , Monica Galleano , Barbara Piotrkowski
DOI: 10.1016/J.ABB.2018.03.041
关键词: Quercetin 、 Pharmacology 、 Chemistry 、 Nitric oxide synthase 、 Glutathione 、 Superoxide dismutase 、 Oxidative stress 、 Glutathione peroxidase 、 Superoxide 、 NADPH oxidase
摘要: Abstract This study investigated the effects of a quercetin-supplemented diet on biochemical changes installed in heart NO-deficient rats terms oxidants production and NO bioavailability determinants. Sprague-Dawley were subjected to Nω-nitro- l -arginine methyl ester ( -NAME) treatment (360 mg/L -NAME drinking water, 4 d) with or without supplementation quercetin (4 g/kg diet). administration led increased blood pressure (BP) (30%), decreased nitric oxide synthase (NOS) activity (50%), increases NADPH oxidase (NOX)-dependent superoxide anion (60%) p47phox protein level (65%). The co-administration prevented increase BP activation NOX but did not modify decrease NOS caused by -NAME. In addition, affected oxidative stress parameters as glutathione oxidation, activities oxidant detoxifying enzymes dismutase, peroxidase, catalase. Thus, counteracts determinants in vivo, essentially through controlling NOX-mediated production.
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