Regulation of the self-renewal ability of tissue stem cells by tumor-related genes.
作者： Kazuhito Naka , Masako Ohmura , Atsushi Hirao
关键词: Clinical uses of mesenchymal stem cells 、 Cellular differentiation 、 Stem cell 、 Stem cell marker 、 Progenitor cell 、 Biology 、 Cell biology 、 Stem cell theory of aging 、 Cancer stem cell 、 Adult stem cell
摘要: Stem cells are defined by both their ability to produce stem cells, a property known as self-renewal, and give rise differentiated progeny. One of the hallmarks tissue cell is its adoption non-dividing, undifferentiated state called quiescence. The sustain quiescence crucial for function in several tissues. In this review, we discuss how properties affected products tumor-related genes such ATM, PTEN FOXO. Recent advances research achieved using mouse genetics have provided novel evidence that numerous genes, which control genomic stability, proliferation survival, also closely associated with regulation self-renewal. These findings support notion cancer share common properties. Further investigation may pave way successful cell-based approaches regenerative medicine therapy.
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