PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry

摘要: Previous studies have demonstrated that a small subpopulation of brain tumor cells share key characteristics with neural stem/progenitor in terms phenotype and behavior. These findings suggest tumors might contain “cancer stem cells” are critical for growth. However, the molecular pathways governing such cell-like behavior remain largely elusive. Our previous study suggests phosphatase tensin homologue deleted on chromosome 10 (PTEN) suppressor gene, one most frequently mutated genes glioblastomas, restricts cell proliferation vivo. In present study, we sought to determine role PTEN long-term maintenance properties, cycle entry progression, growth factor dependence gene expression. results demonstrate an enhanced self-renewal capacity G0-G1 decreased dependency Pten null neural/stem progenitor cells. Therefore, loss leads physiological changes, which collectively sufficient increase pool self-renewing promote their escape from homeostatic mechanisms control.