Inhibition and motor control in the developing zebrafish spinal cord

摘要: Vertebrate locomotion relies on oscillatory activity along the spinal cord. Inhibition is involved in controlling alternation of between each side and contributes modulating propagation termination locomotor activity. Spinal inhibitory neurons are thought to regulate these mechanisms but exact contribution specific cell types remains difficult tackle during active locomotion. In past two decades, use transparent zebrafish larva has enabled morphological, functional, genetic characterization neurons. A wide range new optical tools been developed monitor manipulate genetically targeted populations. Combining techniques with conventional electrophysiology will provide a better understanding interneurons regulating essential features patterns.