Neuronal correlates of the dominant role of GABAergic transmission in the developing mouse locomotor circuitry

摘要: GABA and glycine are the primary fast inhibitory neurotransmitters in mammalian spinal cord, but they differ their regulatory functions, balancing neuronal excitation locomotor circuitry cord. This review focuses on unique role of GABAergic transmission during assembly circuitry, from early embryonic stages when GABA(A) receptor-activated membrane depolarizations increase network excitation, to period postnatal development, inhibition plays a coordinating patterns locomotor-like motor activity. To gain insight into mechanisms that underlie dominant contribution activity period, we examined morphological electrophysiological properties subpopulation commissural interneurons fit well with putative function as integrated components rhythm-coordinating networks mouse