Gastrointestinal Stromal Tumors: Molecular Markers and Genetic Subtypes
作者： Christine M. Barnett , Christopher L. Corless , Michael C. Heinrich
DOI: 10.1016/J.HOC.2013.07.003
关键词: Medicine 、 PDGFRA 、 Stromal cell 、 Cancer research 、 Pathology 、 Kinase 、 GiST
摘要: Abstract Mutation-activated signaling from the KIT and PDGFRA kinases has been successfully targeted in gastrointestinal stromal tumors (GISTs), with subtle differences between mutations serving to refine prognosis more precisely tailor therapy. There is a growing understanding of molecular drivers GISTs lacking or PDGFRA, so called wild-type GISTs, further aiding management decisions. This article provides an overview all known subtypes GIST information about clinical correlates, treatment, depending on subtype.
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sci-hub.se 参考文章(79)
Helen E. Remotti, Frank Aldenborg, Jeanne M. Meis-Kindblom, Lars Gunnar Kindblom, Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. American Journal of Pathology. ,vol. 152, pp. 1259- 1269 ,(1998)
Nick J. Dibb, Stephen M. Dilworth, Clifford D. Mol, Switching on kinases: oncogenic activation of BRAF and the PDGFR family. Nature Reviews Cancer. ,vol. 4, pp. 718- 727 ,(2004) , 10.1038/NRC1434
Maria Debiec-Rychter, Jan Cools, Herlinde Dumez, Raf Sciot, Michel Stul, Nicole Mentens, Hilde Vranckx, Bartosz Wasag, Hans Prenen, Johannes Roesel, Anne Hagemeijer, Allan Van Oosterom, Peter Marynen, Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants Gastroenterology. ,vol. 128, pp. 270- 279 ,(2005) , 10.1053/J.GASTRO.2004.11.020
Heikki Joensuu, Adjuvant treatment of GIST: patient selection and treatment strategies. Nature Reviews Clinical Oncology. ,vol. 9, pp. 351- 358 ,(2012) , 10.1038/NRCLINONC.2012.74
Thomas de Raedt, Jan Cools, Maria Debiec–Rychter, Hilde Brems, Nicole Mentens, Raf Sciot, Jacques Himpens, Ivo de Wever, Patrick Schöffski, Peter Marynen, Eric Legius, Intestinal neurofibromatosis is a subtype of familial GIST and results from a dominant activating mutation in PDGFRA. Gastroenterology. ,vol. 131, pp. 1907- 1912 ,(2006) , 10.1053/J.GASTRO.2006.07.002
Isabelle Hostein, Nicolas Faur, Charlotte Primois, Frédérique Boury, Jérome Denard, Jean-François Emile, Pierre-Paul Bringuier, Jean-Yves Scoazec, Jean-Michel Coindre, BRAF Mutation Status in Gastrointestinal Stromal Tumors American Journal of Clinical Pathology. ,vol. 133, pp. 141- 148 ,(2010) , 10.1309/AJCPPCKGA2QGBJ1R
Ricardo Celestino, Jorge Lima, Alexandra Faustino, João Vinagre, Valdemar Máximo, António Gouveia, Paula Soares, José Manuel Lopes, Molecular alterations and expression of succinate dehydrogenase complex in wild-type KIT/PDGFRA/BRAF gastrointestinal stromal tumors European Journal of Human Genetics. ,vol. 21, pp. 503- 510 ,(2013) , 10.1038/EJHG.2012.205
C. Tarn, L. Rink, E. Merkel, D. Flieder, H. Pathak, D. Koumbi, J. R. Testa, B. Eisenberg, M. von Mehren, A. K. Godwin, Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 8387- 8392 ,(2008) , 10.1073/PNAS.0803383105
Katherine A. Janeway, Karen H. Albritton, Annick D. Van Den Abbeele, Gina Z. D'Amato, Paolo Pedrazzoli, Salvatore Siena, Joel Picus, James E. Butrynski, Marcus Schlemmer, Michael C. Heinrich, George D. Demetri, Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib. Pediatric Blood & Cancer. ,vol. 52, pp. 767- 771 ,(2009) , 10.1002/PBC.21909
A. Buffet, A. Venisse, V. Nau, I. Roncellin, V. Boccio, N. Le Pottier, M. Boussion, C. Travers, C. Simian, N. Burnichon, N. Abermil, J. Favier, X. Jeunemaitre, A.-P. Gimenez-Roqueplo, A Decade (2001–2010) of Genetic Testing for Pheochromocytoma and Paraganglioma Hormone and Metabolic Research. ,vol. 44, pp. 359- 366 ,(2012) , 10.1055/S-0032-1304594