Human Immunodeficiency Virus-Associated Chronic Lung Disease in Children and Adolescents in Zimbabwe: Chest Radiographic and High-Resolution Computed Tomographic Findings.

摘要: Background: Chronic respiratory symptoms are common among children living with human immunodeficiency virus (HIV). We investigated the radiological features of chronic lung disease in aged 6-16 years receiving antiretroviral therapy for ≥6 months Harare, Zimbabwe. Methods: Consecutive participants from a HIV clinic underwent clinical assessment and chest radiography. Participants an abnormal radiograph (assessed by clinician) and/or those meeting case definition high-resolution computed tomography (HRCT). Radiological studies were scored independently blindly 2 thoracic radiologists. Relationships between abnormalities function examined. Results: Among 193 (46% female; median age, 11.2 years; interquartile range, 9.0-12.8 years), CD4 cell count was 720/µL (473-947/µL), 79% had (HIV) load <400 copies/mL. The most radiographic finding ring/tramline opacities (55 participants; 29%). HRCT scans evaluated 84 (69%); decreased attenuation (present 43%) dominant abnormality seen. extent strongly correlated both severity bronchiectasis (rs = 0.68 P < .001 both). also negatively forced expiratory volume first second expiration -0.52), vital capacity -0.42), flow, midexpiratory phase -0.42) (P all). Conclusions: findings suggest that obliterative bronchiolitis may be major cause our cohort. Further to understand pathogenesis natural history urgently needed.