Fever from the forest: prospects for the continued emergence of sylvatic dengue virus and its impact on public health.

摘要: The four dengue virus (DENV) serotypes that circulate among humans emerged independently from ancestral sylvatic progenitors were present in non-human primates, following the establishment of human populations large and dense enough to support continuous inter-human transmission by mosquitoes. This sylvatic-DENV cycle still exists is maintained primates Aedes mosquitoes forests Southeast Asia West Africa. Here, we provide an overview ecology molecular evolution DENV its potential for adaptation transmission. We also emphasize how study will improve our ability understand, predict and, ideally, avert further emergence.