Increased tissue endothelin immunoreactivity in atherosclerotic lesions associated with acute coronary syndromes
作者： A ZEIHER
DOI: 10.1016/S0140-6736(94)90571-1
关键词: Biopsy 、 Internal medicine 、 Pathophysiology 、 Endothelins 、 Vasoconstriction 、 Endothelin receptor 、 Medicine 、 Coronary artery disease 、 Cardiology 、 Immunohistochemistry 、 Angina
摘要: Acute coronary syndromes are accompanied by exaggerated vasoconstriction. Since thrombin induces production of the potent vasoconstrictor endothelin-1, we used immunohistochemistry on atherosclerotic specimens from 30 consecutive patients. Endothelin-1-like immunoreactivity was present in 5 9 (55%) lesions patients with stable angina, 6 7 (86%) crescendo and all 14 angina at rest. Endothelin-1 most common areas a positive Prussian-blue reaction indicative previous intraplaque haemorrhage. Tissue endothelin-1-like might contribute to
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