Pathogenesis of rhegmatogenous retinal detachment: predisposing anatomy and cell biology.

摘要: Background The pathogenesis of rhegmatogenous retinal detachment is complex, and our knowledge the exact mechanism vitreoretinal attachment remains incomplete. Methods We performed a Medline, Ovid, EMBASE search using words rhegmatogenous, detachment, vitreous, adhesion. All appropriate articles were reviewed, evidence was compiled. Results Cortical vitreous contains fibrillar collagens type II, V/XI, IX. inner limiting membrane retina I, IV, VI, XVIII as well numerous other glycoproteins potential adhesion molecules. distribution age-related changes in structure these molecules play an important role formation break, which may compromise disrupt normal mechanisms neurosensory Conclusion Rhegmatogenous development intimately related to aging culminating posterior with regions persistent tangential traction predisposing tear formation. A complex interplay factors such weakening adhesion, migration base, molecular at interface are focal areas precipitating detachment. Once formed, passage liquefied through break overwhelm neurosensory-retinal pigment epithelium perpetuating extending causing visual loss. To understand events underlying so that new therapies can be developed, it appreciate structural organization biology liquefaction