Vitamin D Related Genes, CYP24A1 and CYP27B1, and Colon Cancer Risk

摘要: Genetic association studies investigating the role of vitamin D in colon cancer have primarily focused on receptor (VDR), with limited data available for other genes pathway, including activating enzyme 1-alpha hydroxylase (CYP27B1) and deactivating 24-alpha (CYP24A1). We evaluated whether 12 tagging single nucleotide polymorphisms (SNP) CYP24A1, identified by resequencing gene 32 Caucasian samples, 1 SNP CYP27B1 were associated risk. In addition, we these two modify associations between one hand total intake UV-weighted sun exposure other, as well variants VDR. Unconditional logistic regression was used to calculate odds ratios (OR) 95% confidence intervals (95% CI) haplotypes CYP24A1 a multicenter population-based case-control study 1,600 cases 1,949 controls. The polymorphism IVS4-66T > G showed statistically significant risk overall, particularly proximal cancer. When stratified anatomic site, also found three distal (IVS4 + 1653C T: OR CT/TT versus CC, 0.81; CI, 0.68-0.96; IVS9 198T C: CC TT, 1.33; 1.03-1.73; within whites only: +4125bp 3' STPC G: GG 1.44; 1-2.05). possible interaction observed. As this is first evaluate relation cancer, additional are needed confirm results.