Nonclassical Effects of 1α,25-Dihydroxyvitamin D3 and Its Analogs
作者： A. Verstuyf , L. Verlinden , S. Segaert , E. van Etten , C. Mathieu
DOI: 10.1159/000057472
关键词:
摘要: The activated form of vitamin D 3 , 1α,25(OH) 2 not only plays a central role in bone and calcium metabolism but has also potent antiproliferative prodifferentiating effects. Moreover, the combined presence 25(OH)D -1α-hydroxylase as well receptor several tissues introduced idea paracrine for . By introducing chemical modifications into flexible parent molecule whole generation analogs was created. Due to clear dissociation effects from calcemic effects, these can be used treatment disorders non-classical applications.
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