Regulatory T cells in the prevention of mucosal inflammatory diseases: Patrolling the border

摘要: Regulatory T (Treg) cells are important contributors to the maintenance of immune tolerance in periphery, and deficiency Tregs is associated with various immunopathic diseases. Murine models autoimmune autoinflammatory disorders have helped elucidate how involved these A feature common between human mice that lack one or another key Treg subsets occurrence mucosal inflammation. The relatively fragile surface represents a complex system normally well equipped ward off harmful pathogens yet at same time inhibitory destructive inflammatory responses biologically needed (probiotic) microorganisms, other environmental antigens e.g. nutrients. We here discuss importance maintaining surfaces outcomes function. intestinal tract its diseases provide "point departure" for discussion, but similar considerations could apply linings exposed environment such as members digestive system. However, lungs, bile ducts, urogenital susceptible poorly understood states possibly depend on dysfunction cells. Finally there now potential therapies predicated reconstitution effective function