Inflammatory bowel disease: beyond the boundaries of the bowel

摘要: Dysregulated inflammation in the gut, designated clinically as inflammatory bowel disease (IBD), is manifested by prototypic phenotypes of an Arthus-like reaction restricted to mucosa colon, ulcerative colitis, or a transmural granulomatous reaction, Crohn’s disease, indeterminate form two polar types. That IBD can trespass boundaries has long been known, with articular, ophthalmologic, cutaneous, hepatobiliary other complications/associations – some autoimmune and others not affecting significant numbers patients IBD. Also notable frequency diagnosis IBD-type diseases on background systemic, (mostly myelo-hematological) disorders, associated alterations either (or both) innate adaptive arms immune response. Finally, cases are reported occur adverse effect TNF inhibitors. Bone marrow transplant proven be only curative measure for above...