Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.
作者： Takayuki Tomita , Takanori Kanai , Yasuhiro Nemoto , Teruji Totsuka , Ryuichi Okamoto
DOI: 10.4049/JIMMUNOL.180.1.383
关键词:
摘要: … is constitutively produced by intestinal goblet epithelial cells (8), 2) IL-7 transgenic (Tg) mice, in which IL-7 overexpression was driven by SRα promotor, developed chronic …
elsevier.com
jimmunol.org
aai.org
researchgate.net 参考文章(36)
Mamoru Watanabe, Noriaki Watanabe, Yasushi Iwao, Haruhiko Ogata, Takanori Kanai, Yoshitaka Ueno, Masaharu Tsuchiya, Hiromasa Ishii, Sadakazu Aiso, Sonoko Habu, Toshifumi Hibi, The serum factor from patients with ulcerative colitis that induces T cell proliferation in the mouse thymus is interleukin-7. Journal of Clinical Immunology. ,vol. 17, pp. 282- 292 ,(1997) , 10.1023/A:1027322631036
R. Balfour Sartor, William J. Sandborn, Kirsner's inflammatory bowel disease 世界胃肠病学杂志(英文版). ,(2004)
Stephen C. Jameson, Maintaining the norm: T-cell homeostasis Nature Reviews Immunology. ,vol. 2, pp. 547- 556 ,(2002) , 10.1038/NRI853
Shin Makita, Takanori Kanai, Yasuhiro Nemoto, Teruji Totsuka, Ryuichi Okamoto, Kiichiro Tsuchiya, Masafumi Yamamoto, Hiroshi Kiyono, Mamoru Watanabe, Intestinal Lamina Propria Retaining CD4+CD25+ Regulatory T Cells Is A Suppressive Site of Intestinal Inflammation Journal of Immunology. ,vol. 178, pp. 4937- 4946 ,(2007) , 10.4049/JIMMUNOL.178.8.4937
Kevin J. Maloy, Fiona Powrie, Regulatory T cells in the control of immune pathology Nature Immunology. ,vol. 2, pp. 816- 822 ,(2001) , 10.1038/NI0901-816
Caroline Fluur, Angelo De Milito, Terry J. Fry, Nancy Vivar, Liv Eidsmo, Ann Atlas, Cristina Federici, Paola Matarrese, Mariantonia Logozzi, Eva Rajnavölgyi, Crystal L. Mackall, Stefano Fais, Francesca Chiodi, Bence Rethi, Potential Role for IL-7 in Fas-Mediated T Cell Apoptosis During HIV Infection Journal of Immunology. ,vol. 178, pp. 5340- 5350 ,(2007) , 10.4049/JIMMUNOL.178.8.5340
Terry J. Fry, Crystal L. Mackall, The Many Faces of IL-7: From Lymphopoiesis to Peripheral T Cell Maintenance The Journal of Immunology. ,vol. 174, pp. 6571- 6576 ,(2005) , 10.4049/JIMMUNOL.174.11.6571
M Watanabe, Y Ueno, T Yajima, Y Iwao, M Tsuchiya, H Ishikawa, S Aiso, T Hibi, H Ishii, Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes Journal of Clinical Investigation. ,vol. 95, pp. 2945- 2953 ,(1995) , 10.1172/JCI118002
Yasuhiro Nemoto, Takanori Kanai, Shin Makita, Ryuichi Okamoto, Teruji Totsuka, Kiyoshi Takeda, Mamoru Watanabe, Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastroenterology. ,vol. 132, pp. 176- 189 ,(2007) , 10.1053/J.GASTRO.2006.10.035
Francesca Di Rosa, Reinhard Pabst, The bone marrow: a nest for migratory memory T cells Trends in Immunology. ,vol. 26, pp. 360- 366 ,(2005) , 10.1016/J.IT.2005.04.011