Diacylglycerol kinase defect in a Drosophila retinal degeneration mutant rdgA.
作者： H Inoue , T Yoshioka , Y Hotta
DOI: 10.1016/S0021-9258(18)83648-1
关键词: Mutant 、 Drosophila melanogaster 、 Gene dosage 、 Kinase activity 、 Phospholipase C 、 Retinal degeneration 、 Cell biology 、 Biochemistry 、 Biology 、 Mutation 、 Diacylglycerol kinase
摘要: Abstract The Drosophila visual mutant rdgA is known to show age-dependent retinal degeneration with defective diacylglycerol (DG) kinase activity. In this study we examined DG activity of several mutants and found that only eyes showed the lack in a gene dosage-dependent manner. enzyme already absent at time eclosion from pupal case when not yet apparent. To examine whether dosage effect holds for other enzymes related phosphatidylinositol turnover, phospholipase C was analyzed which did any effect. Therefore, it strongly suggested correlates closely activity, defect primary cause mutant.
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