Regulación del splicing alternativo: Implicaciones en el diagnóstico y tratamiento del cáncer
作者： Nancy Martínez-Montiel , Nora Rosas-Murrieta , Rebeca Martínez-Contreras
DOI: 10.1016/J.MEDCLI.2014.02.021
关键词: Humanities 、 Medicine
摘要: Resumen La expresion de la informacion genetica es regulada por procesos como el splicing del ARN mensajero, mecanismo propuesto Phil Sharp y Richard Roberts, quienes demostraron existencia secuencias intronicas, las cuales interrumpen a mayoria los genes estructurales en eucariotes deben ser removidas con gran precision. Dicha remocion intrones se denomina , permite generar variantes proteicas partir un solo gen, cada una funciones diversas y, menudo, antagonicas. Actualmente sabe que principal fuente diversidad proteica, ya 70% humanos lo sufren, defectos este proceso originan hasta 50% enfermedades geneticas, incluido cancer. Cuando estos presentan involucrados adhesion, proliferacion ciclo celular, repercuten progresion cancerosos cuyo diagnostico, tratamiento prognosis puede determinarse base su perfil .
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