Splicing Regulation in Drosophila Sex Determination
作者： P. Förch , J. Valcárcel
DOI: 10.1007/978-3-662-09728-1_5
关键词:
摘要: Posttranscriptional regulation is of fundamental importance for establishing the gene expression programs that determine sexual identity in fruitfly Drosophila melanogaster. The protein Sex-lethal acts as a master regulatory switch, being expressed exclusively female flies and inducing female-specific patterns alternative splicing on target genes. As consequence, other factors are sex-specific manner, these control somatic germline differentiation, behavior X chromosome dosage compensation. Here, we review molecular mechanisms responsible determination.
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