作者: Hubert Amrein
DOI: 10.1186/GB-2000-1-6-REVIEWS1030
关键词: Genetics 、 Dosage compensation 、 X chromosome 、 Mechanism (biology) 、 Regulation of gene expression 、 Gene 、 Human genetics 、 Biology 、 Gene expression 、 RNA
摘要: From worms to humans, recognizing and modifying a specific chromosome is essential for dosage compensation, the mechanism by which equal X-linked gene expression in males females achieved. Recent molecular genetic biochemical studies have provided new insights into how regulatory factors Drosophila are recruited assembled on X chromosome, leading hypertranscription of its genes.