Reduced levels of histone H3 acetylation on the inactive X chromosome in human females.
作者： Barbara A. Boggs , Bernadette Connors , Richard E. Sobel , A. Craig Chinault , C. David Allis
DOI: 10.1007/BF02524648
关键词:
摘要: Novel antibodies were generated that are highly selective for either acetylated or unacetylated isoforms of histone H3, the form H4 in organisms as diverse Tetrahymena and humans. Using these pair-wise sets immunocytological analyses, we demonstrate inactive X chromosome is hypoacetylated both H3 female mammalian cells, whereas antibody recognizes identifies all chromosomes uniformly. These data verify extend previous results suggest hypoacetylation core histones may be a general feature chromatin along chromosome.
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