Genes, chromatin, and breast cancer: an epigenetic tale.

摘要: The production of heritable changes in gene expression is the driving force development and progression breast cancer. Such can result from mutations or epigenetic events such as hypermethylation DNA hypoacetylation histones. Histone acetylation methylation are major determinants chromatin structure, structure a primary regulator transcription. Cancer cells frequently contain both mutated genes with altered due to one more mechanisms. This review describes that disrupt normal architecture modify key cancer cells. structural integrity latter usually intact, but their has been substantially promoter region deacetylation histones interact Genes affected by cancers include HoxA5, p21WAF, gelsolin, BRCA1, BRCA2, E-cadherin, steroid hormone receptors, retinoic acid receptor II. Because these modifications reversible treatment certain drugs, they represent vulnerabilities cell be exploited novel targets for new prevention therapeutic strategies.