Epigenetic downregulation of the retinoic acid receptor-beta2 gene in breast cancer.
作者： Martin Widschwendter , Jennifer Berger , Hannes M. Müller , Alain G. Zeimet , Christian Marth
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摘要: A growing body of evidence supports the hypothesis that retinoic acid receptor beta2 (RAR-beta2) gene is a tumor suppressor which induces apoptosis and chemopreventive therapeutic effects retinoids are due to induction RAR-beta2. During breast cancer progression, RAR-beta2 reduced or even lost. It known from studies other tumor-suppressor genes methylation 5'-region cause loss expression. Several groups demonstrated this also true for in by treating cell lines with demethylating agent examining expression response challenge acid. Studies using sodium bisulfite genomic sequencing as well specific PCR showed number tissue signs methylation. The was unmethylated non-neoplastic normal tissues. combination agents histone deacetylase inhibitors acts synergistically inhibit growth. This review presents data suggest treatment patients followed may offer new modality. Both time commencement chemoprevention choice substances able either prevent de novo reverse methylation-caused silencing be important considerations.
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