Alternatively Spliced Genes

摘要: An important step of eukaryotic gene expression is pre-mRNA splicing, the process removing intervening sequences (introns) from nascent transcript (messenger RNA precursor, or pre-mRNA). The discovery split genes in viral genome and subsequent research field splicing have greatly advanced our understanding mammalian regulation. Studies on also facilitated sequence analyses human genome. With completion sequencing, it now further appreciated that alternative play critical roles regulating enhancing genetic diversity. Evolutionarily, basic machinery for appears to be highly conserved among different species metazoans. In Saccharomyces cerevisiae , although only a small percentage undergo more than 100 been identified are either dedicated involved splicing. mammals, crucial because vast majority transcription units contain one introns must accurately removed form mature functional messenger (mRNA) species. this chapter, we review current knowledge about with special emphasis aspects related pathogenesis treatment diseases. Keywords: Pre-mRNA; Exon; Intron; Pre-mRNA Splicing; UsnRNPs; Spliceosome; 5′ 3′ Splice Sites; Alternative Splicing; Splicing Regulatory Elements; Splicing Regulators