Bcr-abl truncation mutations
作者： Wanlong Ma , Maher Albitar
DOI:
关键词: Truncation (statistics) 、 Molecular biology 、 Tyrosine-kinase inhibitor 、 Complementary DNA 、 Biology 、 Recombinant DNA 、 Tyrosine kinase 、 Kinase 、 Messenger RNA 、 Gene
摘要: Truncation variants of BCR-ABL mRNA that produces proteins with a truncated C-terminus and its role in resistance to treatment kinase inhibitors is described. Vectors for expressing the gene products are described as well recombinant cells express from cDNA constructs. Also provided methods compositions kits detecting truncation variants. determining prognosis patient diagnosed having myeloproliferative disease, predicting likelihood tyrosine inhibitor disease. Additionally, screening domain which rely on also disclosed.
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