Hyperthermic spreading depressions in the immature rat hippocampal slice.
作者： Jie Wu , Robert S. Fisher
DOI: 10.1152/JN.2000.84.3.1355
关键词: Endocrinology 、 Ionic homeostasis 、 Internal medicine 、 Hippocampal formation 、 Chemistry 、 Hippocampal slice 、 Pathophysiology 、 Electrophysiology 、 Neuroscience
摘要: Febrile seizures are the most common seizure type in children (6 mo to 5 yr). The pathophysiology of febrile is unknown. Current genetic studies show that some result from channelopathies. We have performed electrophysiological experiments vitro hippocampal slices test a novel hypothesis disordered regulation ionic homeostasis underlies genesis seizures. In transverse CA1 104 rats, temperature increase 34° 40°C produced series spreading depressions (SDs), called hyperthermic SDs. SDs were age-dependent, occurring only 1/17 8–16 day-old animals, 44/49 17–60 and 11/20 rats older than 60 days. usually occurred on rising phase temperature. mean trigger first SD was 38.8 ± 1.3°C (mean SD, n = 44). induced reversible loss evoked synaptic potentials dramatic decrease input r...
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