Role of Tropomyosin in the Regulation of Contraction in Smooth Muscle
作者： Steve Marston , M. El-Mezgueldi
DOI: 10.1007/978-0-387-85766-4_9
关键词: Calmodulin-binding proteins 、 Actin 、 Caldesmon 、 Myofilament 、 Calmodulin 、 Skeletal muscle 、 Tropomyosin 、 Biophysics 、 Smooth muscle contraction 、 Chemistry
摘要: Smooth muscle contraction is due to the interaction ofmyosin filaments with thin filaments. Thin are composed of actin, tropomyosin, caldesmon and calmodulin in ratios 14:2:1:1. Tissue specific isoforms act beta tropomyosin expressed smooth muscle. Compared skeletal cooperative activation actomyosin enhanced by tropomyosin: unit size 10 equilibrium between on off states shifted towards state. The muscle-specific actin-bindingprotein caldesmon, together regulates activity filament response Ca2+. Caldesmon control tropomyosin-mediated transition offactivity states.
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