Live attenuated measles and mumps viral strain-containing vaccines and hearing loss: Vaccine Adverse Event Reporting System (VAERS), United States, 1990--2003.

摘要: Hearing loss (HL) is a known complication of wild measles and mumps viral infections. As vaccines against contain live attenuated strains, it biologically plausible that in some individuals HL could develop as vaccination and/or mumps. Our objectives for this study were: to find describe all cases reported the scientific literature US Vaccine Adverse Events Reporting System (VAERS) period 1990--2003; determine reporting rate after strain-containing (MMCV) administration. We searched published reports identified with MMCV. also MMCV administration submitted VAERS from 1990 through 2003 determined dose-adjusted HL. main outcome measure was immunization which were classified idiopathic. found 11 case following The review 44 likely idiopathic sensorineural onset majority consistent incubation periods viruses. Based on annual usage measles-mumps-rubella (MMR) vaccine, we estimated be 1 per 6-8 million doses. Thus, has been VAERS. Further studies are needed better understand if there causal relationship between