Phytochemical Screening and Antinociceptive and Antidiarrheal Activities of Hydromethanol and Petroleum Benzene Extract of Microcos paniculata Barks

摘要: Introduction. Microcos paniculata is traditionally used for treating diarrhea, wounds, cold, fever, hepatitis, dyspepsia, and heat stroke. Objective. To investigate the qualitative phytochemical constituents of hydromethanol (HMPB) petroleum benzene extract barks (PBMPB) to evaluate their antinociceptive antidiarrheal activities. Methods. Phytochemical activities were determined evaluated by different tests such as Molisch’s, Fehling’s, Mayer’s, Wagner’s, Dragendorff’s, frothing, FeCl3, alkali, Pew’s, Salkowski’s test, general test glycosides, Baljet NH4OH formalin-induced paw licking, acetic acid-induced writhing, tail immersion, hot plate tests, castor oil MgSO4 induced diarrheal tests. Results. These extracts revealed presence saponins, flavonoids, triterpenoids significantly ( , versus control) reduced licking abdominal writhing mice. At 30 min after administration, PBMPB significant increase in latency immersion test. In HMPB 200 mg/kg showed response at administration. Moreover, both inhibited percentage diarrhea models. Conclusion. Study results indicate that M. may provide a source plant compounds with