Vanda roxburghii: an experimental evaluation of antinociceptive properties of a traditional epiphytic medicinal orchid in animal models.

摘要: Ethnopharmacological approach has explored several leads from plant sources to identify potential new drugs for various diseases including pain. Vanda roxburghii R. Br., an epiphytic orchid is widely distributed throughout Bangladesh. The root of this a folkloric reputation treat inflammations, fever, dyspepsia, bronchitis, hiccough, piles, snake bites, and the nervous system. In study therefore, we aimed investigate antinociceptive cytotoxic properties extracts V. roxburghii. Dried powder aerial was extracted with methanol (VRM) resultant fractionated into petroleum ether (VRP), chloroform (VRC), ethyl acetate (VRE), residual aqueous fraction (VRA). effect evaluated in mice using acetic acid-induced writhing, formalin injection, hot plate tests. brine shrimp lethality bioassay vitro used evaluate activity extracts. writhing test, treated different fractions (12.5, 25, 50 mg/kg, i.p.) exhibited reduced number writhing. Amongst, VRE showed highest at all three concentrations (43.65, 71.34, 80.23 %, respectively) dose-dependent manner. Secondly, VRC displayed reduction paw licking time during first phase test (by 15.00, 37.05, 56.44 %, as well second 20.55, 49.08, 59.81 %, respectively). treatment doses 25 50 mg/kg both increased latency after 30 min. All lower cytotoxicity compared standard drug vincristine sulfate bioassay. Overall studies suggest that effective potent analgesic toxicity. Our findings support previous claims traditional uses inflammatory disorders.