Large screen approaches to identify novel malaria vaccine candidates

摘要: Until recently, malaria vaccine development efforts have focused almost exclusively on a handful of well characterized Plasmodium falciparum antigens. Despite dedicated work by many researchers different continents spanning more than half century, successful remains elusive. Sequencing the P. genome has revealed five thousand genes, providing foundation for systematic approaches to discover candidate We are taking advantage this wealth information new antigens that may be effective targets. Herein, we describe large-scale screening identify targets either antibody responses or T cell using human specimens collected in Controlled Human Malaria Infections (CHMI) under conditions natural exposure field. These genome, proteome and transcriptome based offer enormous potential an efficacious vaccine.