Prognostic significance of IFITM1 expression and correlation with microvessel density and epithelial-mesenchymal transition signature in lung adenocarcinoma.
作者： Young Wha Koh , Jae-Ho Han , Dongjun Jeong , Chang-Jin Kim
DOI: 10.1016/J.PRP.2019.152444
关键词: Pathology 、 Vimentin 、 Epithelial–mesenchymal transition 、 Immunohistochemistry 、 Angiogenesis 、 Microvessel 、 Adenocarcinoma 、 CD31 、 Medicine 、 Lung
摘要: Abstract We evaluated the relationship between interferon-induced transmembrane protein 1 (IFITM1) expression, epithelial–mesenchymal transition (EMT) signature and angiogenesis in lung adenocarcinoma. Additionally, we examined prognostic significance of IFITM1 according to pTNM stage confirm that can serve as a complement stage. A total 141 adenocarcinoma specimens were retrospectively by immunohistochemical staining for IFITM1, EMT markers (e-cadherin, β-catenin, vimentin), CD31 measure microvessel density. IFITM1was expressed 46.8% specimens. expression was significantly correlated with increased density (P = 0.048). However, not associated three markers. In multivariate analysis, an independent factor overall survival analysis (hazard ratio: 2.59, P = 0.01). Online database data from 720 patients also revealed negative (P
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