Comparing the effectiveness of efavirenz and nevirapine for first-line antiretroviral therapy in a South African multicentre cohort.

摘要: INTRODUCTION Current WHO guidelines for developing countries recommend efavirenz (EFV) and nevirapine (NVP) first-line antiretroviral treatment (ART). This paper compares the effectiveness of EFV NVP among ART-naive patients initiating at 56 public health facilities in South Africa between January 2004 December 2007. METHODS Participants were assigned to or cohorts depending on their baseline ART regimen. Mortality, viral load suppression after 6 months regimen change compared using Cox proportional hazards models logistic regression. RESULTS At initiation, 19 441 (71.1%) started 7909 (28.9%) treatment. The median follow-up period was 9.5 (IQR 4.6-17.7). After adjustment, mortality similar two cohorts, (adjusted HR = 1.07, 95% CI 0.89-1.28). Viral higher cohort overall odds ratio [AOR] 1.29, 1.05-1.59) women aged 16-40 years (AOR 1.35, 1.11-1.63) with CD4 counts <25 cells/µL 1.95, 1.01-3.76). Patients starting 47% less likely 0.53, 0.48-0.59). DISCUSSION These findings suggest superior should be considered during development future high-burden regions.