Preliminary study of hypoxia-related cardiovascular mediator-markers in patients with end-stage renal disease with and without diabetes and the effects of haemodialysis.

摘要: Background Evidence points to activation of pro-inflammatory and pro-thrombotic stimuli during the haemodialysis process in end-stage renal disease (ESRD) with potential predispose cardiovascular events. Diabetes is associated a higher incidence patients. We tested hypothesis that range mediators markers modulate risk are elevated patients diabetes compared those without. Methods Men women (n = 6) without aged 18–90 years receiving were recruited. Blood samples collected analysed pre- post-haemodialysis sessions for (platelet-monocyte conjugates (PMC), oxidised LDL (Ox-LDL), endothelin 1 (ET-1) vascular endothelial growth factor (VEGF-A). Results PMC levels significantly increased after both groups (diabetes p 0.047; non-diabetes 0.005). Baseline VEGF-A was people (p 0.009) post-dialysis reduced (P 0.002). Ox-LDL CRP concentrations not different between nor affected either group post-dialysis. Similarly, ET-1 comparable all at baseline, no change group. Conclusions In this pilot study, we have confirmed circulating PMCs following dialysis irrespective status. This likely be mechanistic offers explanation high rates events haemodialysis. The previously unreported finding diabetic ESRD. Further research merited establish whether marker or mediator (or both)