Nuclear abnormalities in buccal mucosa cells of patients with type I and II diabetes treated with folic acid.
作者： B.C. Gómez-Meda , A.L. Zamora-Perez , T. Muñoz-Magallanes , M.G. Sánchez-Parada , J.J. García Bañuelos
DOI: 10.1016/J.MRGENTOX.2015.12.003
关键词: Oral mucosa 、 Genetics 、 Binucleated cells 、 Endocrinology 、 Medicine 、 Micronucleus test 、 Pyknosis 、 Reactive oxygen species 、 Karyolysis 、 Internal medicine 、 Karyorrhexis 、 Diabetes mellitus
摘要: Abstract Diabetes mellitus (DM) is characterized by high blood glucose. Excessive production of free radicals may cause oxidative damage to DNA and other molecules, leading complications the disease. It be possible delay or reduce such administration antioxidants as folic acid (FA). The objective this study was determine effect FA on nuclear abnormalities (NAs) in oral mucosa patients with DM. NAs (micronucleated cells, binucleated pyknotic nuclei, karyorrhexis, karyolysis, abnormally condensed chromatin, buds) were analyzed 2000 cells from 45 healthy individuals (control group) 55 controlled uncontrolled type I II DM; 35 latter group treated FA. Samples taken before after treatment. An increased rate found DM comparison that control (P
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