An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy
作者： Paul Brownbill , Igor Chernyavsky , Barbara Bottalico , Gernot Desoye , Stefan Hansson
DOI: 10.1016/J.REPROTOX.2016.06.006
关键词: Clinical Practice 、 Risk assessment 、 Pregnancy 、 International network 、 Safety testing 、 Human placenta 、 Pharmacology 、 Weight of evidence 、 Reproductive toxicology 、 Bioinformatics 、 Medicine
摘要: The human placenta is a critical life-support system that nourishes and protects rapidly growing fetus; unique organ, species specific in structure function. We consider the pressing challenge of providing additional advice on safety prescription medicines environmental exposures pregnancy how ex vivo vitro placental models might be advanced to reproducible test systems (HPTSs), refining weight evidence guidance given around compound risk assessment during pregnancy. pharmacokinetics xenobiotic transfer, dysregulated function pregnancy-related pathologies influx/efflux transporter polymorphisms are few caveats could addressed by HPTSs, not focus current mammalian reproductive toxicology systems. An international consortium, “PlaNet”, will bridge academia, industry regulators screen ability standardisation issues surrounding these models, with proven reproducibility for introduction into industrial clinical practice.
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