Ex Vivo Dual Perfusion of the Human Placenta: Disease Simulation, Therapeutic Pharmacokinetics and Analysis of Off-Target Effects
作者： Paul Brownbill , Neil Sebire , Erin V. McGillick , Stacey Ellery , Padma Murthi
DOI: 10.1007/978-1-4939-7498-6_14
关键词:
摘要: In recent years ex vivo dual perfusion of the human placental lobule is seeing an international renaissance in its application to understanding fetal health and development. Here, we discuss methods uses this technique evaluation (1) vascular function, (2) transplacental clearance, (3) hemodynamic oxygenation changes associated with pregnancy complications on structure (4) toxicology post-perfusion tissue architecture.
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