The neurobiology of self-knowledge in depressed and self-injurious youth.

摘要: There is limited information regarding the neurobiology underlying non-suicidal self-injury (NSSI) in clinically-referred youth. However, salience of disturbed interpersonal relationships and disrupted self-processing associated with NSSI suggests neural basis social processes as a key area for additional study. Adolescent participants (N=123; M=14.75 years, SD=1.64) were divided into three groups: plus depression diagnosis (NSSI), only (DEP), healthy controls (HC). In scanner, completed an Interpersonal Self-Processing task by taking direct (own) indirect (mothers', best friends', or classmates') perspectives self-characteristics. Across all perspectives, showed higher BOLD activation limbic areas, anterior posterior cortical midline structures versus DEP HC, while HC greater activity rostrolateral, frontal pole occipital cortex than Moreover, youth heightened responses amygdala, hippocampus, parahippocampus, fusiform when their mothers' perspective, which negatively correlated self-reports mother's support adolescents' emotional distress group. also yielded precuneus cingulate during from classmates' perspective. Findings suggest role disruptions self- emotion-processing, conflicted among depressed adolescents.