Impaired TLR4 and HIF expression in cystic fibrosis bronchial epithelial cells downregulates hemeoxygenase-1 and alters iron homeostasis in vitro
作者： Shashi Chillappagari , Shalini Venkatesan , Virajith Garapati , Poornima Mahavadi , Antje Munder
DOI: 10.1152/AJPLUNG.00167.2014
关键词: Iron homeostasis 、 Oxidative stress 、 Heat shock protein 、 Cell biology 、 Cystic fibrosis 、 TLR4 、 In vitro 、 Biology 、 Hypoxia (medical) 、 Downregulation and upregulation 、 Immunology
摘要: Hemeoxygenase-1 (HO-1), an inducible heat shock protein, is upregulated in response to multiple cellular insults via oxidative stress, lipopolysaccharides (LPS), and hypoxia. In this study, we inve...
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