A comprehensive mechanistic review insight into the effects of micronutrients on toll-like receptors functions.

摘要: Abstract Toll-like receptors (TLRs) are the special proteins for recognition of molecules related to pathogens. In this way, TLRs and secreted cytokines as a result activation involved in inflammation pathways. So far, vivo vitro studies have demonstrated that micronutrients (vitamins & minerals) with broad range effects on body health, can regulate signaling Current review aimed at determining possible mechanisms micronutrient functions. aspect gene expression, inconsistent mRNA level which dependent time, dose type studied TLR. Also, some affect expression mediators namely adaptors like Myeloid differentiation primary response 88 (MyD88). pathways, nuclear factor‐κB (NF-κB) is an important mediator regulated by micronutrients. regulatory phosphorylation reactions may be effective activation/inactivation mediators. addition, zinc indirectly via finger contradictory cascade. conclusion, relationship between complicated depends known internal, external genetic factors form micronutrient, cell type, TLR agonist, time exposure, inflammation, apoptosis, cycle, environmental factors. Some unknown additional mechanistic needed elucidate exact effect signaling.