Zinc finger protein ZBTB20 promotes Toll-like receptor-triggered innate immune responses by repressing IκBα gene transcription.

作者: X. Liu , P. Zhang , Y. Bao , Y. Han , Y. Wang

DOI: 10.1073/PNAS.1301257110

关键词: Molecular biologyInnate immune systemBiologyToll-like receptorTranscription factorZinc fingerPromoterNFKB1IκBαProinflammatory cytokine

摘要: … flox/flox mice (15) with LysM-cre mice (19). MZB20KO (ZBTB20 flox/flox/LysM-Cre ) and control mice (ZBTB20 flox/flox ) were viable, fertile, and normal in size, and they displayed no …

参考文章(41)
Anurupa Dev, Shankar Iyer, Bahram Razani, Genhong Cheng, NF-κB and Innate Immunity Current Topics in Microbiology and Immunology. ,vol. 349, pp. 115- 143 ,(2010) , 10.1007/82_2010_102
L. J EGAN, M. TORUNER, NF-κB Signaling Annals of the New York Academy of Sciences. ,vol. 1072, pp. 114- 122 ,(2006) , 10.1196/ANNALS.1326.009
B.E. Clausen, C. Burkhardt, W. Reith, R. Renkawitz, I. Förster, Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Research. ,vol. 8, pp. 265- 277 ,(1999) , 10.1023/A:1008942828960
Alain Haziot, Naoki Hijiya, Sophie C. Gangloff, Jack Silver, Sanna M. Goyert, Induction of a Novel Mechanism of Accelerated Bacterial Clearance by Lipopolysaccharide in CD14-Deficient and Toll-Like Receptor 4-Deficient Mice The Journal of Immunology. ,vol. 166, pp. 1075- 1078 ,(2001) , 10.4049/JIMMUNOL.166.2.1075
Lai Wei, Golnaz Vahedi, Hong-Wei Sun, Wendy T. Watford, Hiroaki Takatori, Haydee L. Ramos, Hayato Takahashi, Jonathan Liang, Gustavo Gutierrez-Cruz, Chongzhi Zang, Weiqun Peng, John J. O'Shea, Yuka Kanno, Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity. ,vol. 32, pp. 840- 851 ,(2010) , 10.1016/J.IMMUNI.2010.06.003
Kevin F. Kelly, Juliet M. Daniel, POZ for effect – POZ-ZF transcription factors in cancer and development Trends in Cell Biology. ,vol. 16, pp. 578- 587 ,(2006) , 10.1016/J.TCB.2006.09.003
Peter J Murray, Stephen T Smale, Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways Nature Immunology. ,vol. 13, pp. 916- 924 ,(2012) , 10.1038/NI.2391
Dakang Xu, Michelle Holko, Anthony J. Sadler, Bernadette Scott, Shigeki Higashiyama, Windy Berkofsky-Fessler, Melanie J. McConnell, Pier Paolo Pandolfi, Jonathan D. Licht, Bryan R.G. Williams, Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity. Immunity. ,vol. 30, pp. 802- 816 ,(2009) , 10.1016/J.IMMUNI.2009.04.013
Monika Schneider, Albert G Zimmermann, Reid A Roberts, Lu Zhang, Karen V Swanson, Haitao Wen, Beckley K Davis, Irving C Allen, Eda K Holl, Zhengmao Ye, Adeeb H Rahman, Brian J Conti, Timothy K Eitas, Beverly H Koller, Jenny P-Y Ting, The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB Nature Immunology. ,vol. 13, pp. 823- 831 ,(2012) , 10.1038/NI.2378