Association between Naturally Acquired Antibodies to Erythrocyte-Binding Antigens of Plasmodium falciparum and Protection from Malaria and High-Density Parasitemia

摘要: Background. Antibodies targeting blood stage antigens are important in protection against malaria, but the principle targets remain unclear. Erythrocyte-binding (EBAs) erythrocyte invasion ligands used by merozoites and may be of protective immunity, there limited data examining their potential importance. Methods. We examined antibodies among 206 Papua New Guinean children who were treated with antimalarials at enrolment observed prospectively for 6 months reinfection malaria. Immunoglobulin (Ig) G, IgG subclasses, IgM to different regions EBA175, EBA140, EBA181 expressed as recombinant proteins assessed comparison several other merozoite antigens. Results. High levels each EBAs strongly associated from symptomatic malaria high density parasitemia, not risk per se. The predominant subclasses either IgG1 or IgG3, depending on antigen. predominance versus IgG3 reflected structural features specific proteins. was most protection, even those that had an response. Conclusions. appear acquired immunity. These findings support further development vaccine candidates.