Pathways for self-tolerance and the treatment of autoimmune diseases.

摘要: Summary Antigen delivers both immunogenic and tolerogenic signals to lymphocytes. The outcome of antigen exposure represents a complex integration the timing binding with from many other costimulatory pathways. A road map these signalling pathways is only beginning be charted, revealing mechansim action limitations current immunotherapeutic agents points attack for new agents. Ciclosporin tacrolimus interfere in addition blocking signals, thus preventing active establishment tolerance. Corticosteroids inhibit key pathway, NFκB, more specific inhibitors this pathway may allow tolerance actively established while immune responses are blocked. New experimental therapies aim mimic by chronically stimulating receptors or antibodies receptor, block involving CD40 ligand, B7, interleukin 2. Obtaining desired response strategies unpredictable because have roles. cause autoimune diseases has been determined several rare monogenic disorders, inherited deficiencies such as FAS. Common autoimmune disorders biochemically related pathogenesis.