Autoantibodies to coagulation factors
作者： J.-M. R. SAINT-REMY
DOI: 10.1111/J.1365-2516.2010.02229.X
关键词:
摘要: Tolerance to autoantigens such as coagulation factors is the result of censoring mechanisms occurring at level thymus and bone marrow for autoreactive T B cells, respectively. In addition, peripheral mechanisms, both intrinsic extrinsic further control activation cells that have escaped central deletion. Emergence autoimmunity can occur from disturbances these by a number events, many which are incompletely understood. Insight into this clinically important field expected exploitation recent animal models.
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