Timely and large dose of clotting factor IX provides better joint wound healing after hemarthrosis in hemophilia B mice

作者: Ping He , Feixu Zhang , Chen Zhong , Min Li , Jing Zheng

DOI: 10.1007/S12185-019-02639-5

关键词: HemostasisHemarthrosisWound healingGastroenterologyClotting factorImmunostainingInternal medicineMedicineThrombinHematologyFactor IX

摘要: … the major morbidity of severe hemophilia and predisposes it to hemophilic arthropathy (HA). … the joint to blood in wide type (WT) and hemophilic B mice. Specifically, at early time points (…

参考文章(45)
Hui-Feng Lin, Nobuyo Maeda, Oliver Smithies, David L. Straight, Darrel W. Stafford, A Coagulation Factor IX-Deficient Mouse Model for Human Hemophilia B Blood. ,vol. 90, pp. 3962- 3966 ,(1997) , 10.1182/BLOOD.V90.10.3962
T. ELM, D. M. KARPF, K. ØVLISEN, H. PELZER, M. EZBAN, M. KJALKE, M. TRANHOLM, Pharmacokinetics and pharmacodynamics of a new recombinant FVIII (N8) in haemophilia A mice. Haemophilia. ,vol. 18, pp. 139- 145 ,(2012) , 10.1111/J.1365-2516.2011.02608.X
Vikas Bhat, Merissa Olmer, Shweta Joshi, Donald L. Durden, Thomas J. Cramer, Richard FW Barnes, Scott T. Ball, Tudor H. Hughes, Mauricio Silva, James V. Luck, Randy E. Moore, Laurent O. Mosnier, Annette von Drygalski, Vascular remodeling underlies rebleeding in hemophilic arthropathy American Journal of Hematology. ,vol. 90, pp. 1027- 1035 ,(2015) , 10.1002/AJH.24133
L. A. VALENTINO, N. HAKOBYAN, C. ENOCKSON, M. L. SIMPSON, N. C. KAKODKAR, L. CONG, X. SONG, Exploring the biological basis of haemophilic joint disease: experimental studies. Haemophilia. ,vol. 18, pp. 310- 318 ,(2012) , 10.1111/J.1365-2516.2011.02669.X
Y. KASHIWAKURA, T. OHMORI, J. MIMURO, A. YASUMOTO, A. ISHIWATA, A. SAKATA, S. MADOIWA, M. INOUE, M. HASEGAWA, K. OZAWA, Y. SAKATA, Intra-articular injection of mesenchymal stem cells expressing coagulation factor ameliorates hemophilic arthropathy in factor VIII-deficient mice. Journal of Thrombosis and Haemostasis. ,vol. 10, pp. 1802- 1813 ,(2012) , 10.1111/J.1538-7836.2012.04851.X
L. A. Valentino, N. Hakobyan, T. Kazarian, K. J. Jabbar, A. A. Jabbar, Experimental haemophilic synovitis: rationale and development of a murine model of human factor VIII deficiency. Haemophilia. ,vol. 10, pp. 280- 287 ,(2004) , 10.1111/J.1365-2516.2004.00899.X
L. A. Valentino, L. Cong, C. Enockson, X. Song, F. Scheiflinger, E. M. Muchitsch, P. L. Turecek, N. Hakobyan, The biological efficacy profile of BAX 855, a PEGylated recombinant factor VIII molecule. Haemophilia. ,vol. 21, pp. 58- 63 ,(2015) , 10.1111/HAE.12532
Anna G. McDonald, Katie Yang, Harold R. Roberts, Dougald M. Monroe, Maureane Hoffman, Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia. Blood. ,vol. 111, pp. 2046- 2048 ,(2008) , 10.1182/BLOOD-2007-05-092916
A. G. Lau, J. Sun, W. B. Hannah, E. W. Livingston, D. Heymann, T. A. Bateman, P. E. Monahan, Joint bleeding in factor VIII deficient mice causes an acute loss of trabecular bone and calcification of joint soft tissues which is prevented with aggressive factor replacement Haemophilia. ,vol. 20, pp. 716- 722 ,(2014) , 10.1111/HAE.12399
Berthold Hoppe, Thomas Dörner, Coagulation and the fibrin network in rheumatic disease: a role beyond haemostasis Nature Reviews Rheumatology. ,vol. 8, pp. 738- 746 ,(2012) , 10.1038/NRRHEUM.2012.184