Regulation of E2F1 function by the nuclear corepressor KAP1.
作者： Chuangui Wang , Frank J. Rauscher , W. Douglas Cress , Jiandong Chen
关键词: Histone H3 、 Corepressor 、 E2F1 、 Molecular biology 、 Histone deacetylase complex 、 Biology 、 Ring finger 、 E2F1 Transcription Factor 、 Transcription (biology) 、 Retinoblastoma protein
摘要: KAP1 is a nuclear corepressor with conserved domains for RING finger, B boxes, leucine zipper α helical coiled-coil region, plant homeo domain and bromo domain. The finger of cooperatively function as transcription repression by recruiting the histone deacetylase complex NuRD H3 lysine 9-specific methyltransferase SETDB1. Here we report that binds E2F1 factor in retinoblastoma protein (pRb)-independent fashion inhibits activity. stimulates formation E2F1-HDAC1 acetylation. Ectopic expression represses apoptosis functions independent pRb. Depletion endogenous pRb-deficient Saos2 cells RNA interference increases acetylation level, transcriptional activity, sensitizes response to DNA damage. Therefore, contributes negative regulation may serve partial backup prevent E2F1-mediated absence
sci-hub.se 参考文章(34)
J R Nevins, Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth & Differentiation. ,vol. 9, pp. 585- 593 ,(1998)
R. Losson, A. Dierich, F. Cammas, P. Chambon, M. Mark, P. Dolle, Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development. Development. ,vol. 127, pp. 2955- 2963 ,(2000) , 10.1242/DEV.127.13.2955
Joseph R. Nevins, Fang-Tsyr Lin, Weei-Chin Lin, Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation Genes & Development. ,vol. 15, pp. 1833- 1844 ,(2001)
X. Wu, A. J. Levine, p53 and E2F-1 cooperate to mediate apoptosis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 3602- 3606 ,(1994) , 10.1073/PNAS.91.9.3602
Hongzhuang Peng, Gillian E Begg, David C Schultz, Josh R Friedman, David E Jensen, David W Speicher, Frank J Rauscher, Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions. Journal of Molecular Biology. ,vol. 295, pp. 1139- 1162 ,(2000) , 10.1006/JMBI.1999.3402
Yihong Ma, Jing Yuan, Mei Huang, Richard Jove, W. Douglas Cress, Regulation of the Cyclin D3 Promoter by E2F1 Journal of Biological Chemistry. ,vol. 278, pp. 16770- 16776 ,(2003) , 10.1074/JBC.M212702200
T. C. Hallstrom, J. R. Nevins, Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 10848- 10853 ,(2003) , 10.1073/PNAS.1831408100
Chuangui Wang, Xinghua Hou, Subhra Mohapatra, Yihong Ma, W. Douglas Cress, W. Jack Pledger, Jiandong Chen, Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism. Journal of Biological Chemistry. ,vol. 280, pp. 12339- 12343 ,(2005) , 10.1074/JBC.C400536200
Koji Okamoto, Issay Kitabayashi, Yoichi Taya, KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction. Biochemical and Biophysical Research Communications. ,vol. 351, pp. 216- 222 ,(2006) , 10.1016/J.BBRC.2006.10.022
Kirsten Jensen, Carol Shiels, Paul S Freemont, PML protein isoforms and the RBCC/TRIM motif Oncogene. ,vol. 20, pp. 7223- 7233 ,(2001) , 10.1038/SJ.ONC.1204765