MicroRNA-361-5p facilitates cervical cancer progression through mediation of epithelial-to-mesenchymal transition.
作者： Xiaomei Wu , Xiaowei Xi , Qin Yan , Zhenbo Zhang , Bin Cai
DOI: 10.1007/S12032-013-0751-0
关键词: Cervical cancer 、 Epithelial–mesenchymal transition 、 Microarray analysis techniques 、 Oncogene 、 Oncology 、 Cell growth 、 Downregulation and upregulation 、 Biology 、 Internal medicine 、 microRNA 、 In situ hybridization
摘要: The epithelial-to-mesenchymal transition (EMT) promotes cervical cancer progression, and microRNAs have been found to be master regulators of EMT. aim the present study was investigate functional roles miR-361-5p in EMT progression. Differentially expressed miRNAs were screened with microarray analysis SiHa CasKi cells; cellular animal studies used observe impact on cell proliferation; invasion migration ability cells investigated by Transwell wound-healing studies; enzyme-linked immunosorbent assay Western blot methods test protein levels; level specimens detected situ hybridization. MicroRNA-361-5p (miR-361-5p) most upregulated microRNA transferred cells. MiR-361-5p acts as an oncogene enhance proliferation promote invasion, these changes accompanied characteristics is increasingly elevated during carcinoma progression inversely correlated E-cadherin, a marker These findings suggest that oncomicroRNA important factor cancer.
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