Photosynthetic biomaterials: A pathway towards autotrophic tissue engineering

摘要: Engineered tissues are highly limited by poor vascularization in vivo, leading to hypoxia. In order overcome this challenge, we propose the use of photosynthetic biomaterials provide oxygen. Since photosynthesis is original source oxygen for living organisms, suggest that could be a novel approach constant supply independently blood perfusion. study demonstrate bioartificial scaffolds can loaded with solution containing microalgae Chlamydomonas reinhardtii, showing high biocompatibility and activity vitro. Furthermore, when were engrafted mouse full skin defect, observed presence did not trigger native immune response host. Moreover, analyses showed algae survived at least 5 days generating chimeric comprised murine cells. The results represent crucial step towards establishment autotrophic tissue engineering approaches cells treat broad spectrum hypoxic conditions.