An overview of the pharmacology of olive oil and its active ingredients

作者: Francesco Visioli , Alberto Davalos , María‐Carmen López de las Hazas , María Carmen Crespo , Joao Tomé‐Carneiro

DOI: 10.1111/BPH.14782

关键词: OleocanthalNutraceuticalActive ingredientHydroxytyrosolOlive oilContext (language use)PharmacologyBiology

摘要: In addition to providing sensory stimuli, usually taste, smell and sight, olive oil contains a range of minor components, mostly phenolic in nature. These components are endowed with pharmacological or pharma-nutritional properties that the subject active research worldwide. Based on our more than 25 years experience this field, we critically focus what believe most pharmacologically prominent actions constituents oil. Most effects due compounds extra virgin oil, such as hydroxytyrosol oleocanthal (which often mis-categorized vivo antioxidants) concern cardiovascular system. Other potentially beneficial activities still be investigated depth. We conclude that-in context proper diet includes high-quality products-the use contributes achieving sustaining overall health. LINKED ARTICLES: This article is part themed section The Pharmacology Nutraceuticals. To view other articles visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc.

参考文章(156)
Hisham Qosa, Loqman A. Mohamed, Yazan S. Batarseh, Saeed Alqahtani, Baher Ibrahim, Harry LeVine, Jeffrey N. Keller, Amal Kaddoumi, Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice. Journal of Nutritional Biochemistry. ,vol. 26, pp. 1479- 1490 ,(2015) , 10.1016/J.JNUTBIO.2015.07.022
D. Boskou, Olive oil: Properties and processing for use in food Specialty Oils and Fats in Food and Nutrition#R##N#Properties, Processing and Applications. pp. 3- 38 ,(2015) , 10.1016/B978-1-78242-376-8.00001-6
Theodora Psaltopoulou, Theodoros N. Sergentanis, Demosthenes B. Panagiotakos, Ioannis N. Sergentanis, Rena Kosti, Nikolaos Scarmeas, Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis Annals of Neurology. ,vol. 74, pp. 580- 591 ,(2013) , 10.1002/ANA.23944
Juan R. Cubillos-Ruiz, Pedro C. Silberman, Melanie R. Rutkowski, Sahil Chopra, Alfredo Perales-Puchalt, Minkyung Song, Sheng Zhang, Sarah E. Bettigole, Divya Gupta, Kevin Holcomb, Lora H. Ellenson, Thomas Caputo, Ann-Hwee Lee, Jose R. Conejo-Garcia, Laurie H. Glimcher, ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis Cell. ,vol. 161, pp. 1527- 1538 ,(2015) , 10.1016/J.CELL.2015.05.025
Hisham Qosa, Yazan S. Batarseh, Mohamed M. Mohyeldin, Khalid A. El Sayed, Jeffrey N. Keller, Amal Kaddoumi, Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model ACS Chemical Neuroscience. ,vol. 6, pp. 1849- 1859 ,(2015) , 10.1021/ACSCHEMNEURO.5B00190
Stefania D'Angelo, Caterina Manna, Valentina Migliardi, Orazio Mazzoni, Patrizia Morrica, Giovanni Capasso, Gabriele Pontoni, Patrizia Galletti, Vincenzo Zappia, None, Pharmacokinetics and metabolism of hydroxytyrosol, a natural antioxidant from olive oil. Drug Metabolism and Disposition. ,vol. 29, pp. 1492- 1498 ,(2001)
Susan A. Farr, Tulin O. Price, Ligia J. Dominguez, Antonio Motisi, Filippo Saiano, Michael L. Niehoff, John E. Morley, William A. Banks, Nuran Ercal, Mario Barbagallo, Extra Virgin Olive Oil Improves Learning and Memory in SAMP8 Mice Journal of Alzheimer's Disease. ,vol. 28, pp. 81- 92 ,(2012) , 10.3233/JAD-2011-110662
Curtis D. Klaassen, Robert T. Dunn, Tissue-specific expression of rat sulfotransferase messenger RNAs. Drug Metabolism and Disposition. ,vol. 26, pp. 598- 604 ,(1998)
Cinta Valls-Pedret, Aleix Sala-Vila, Mercè Serra-Mir, Dolores Corella, Rafael De la Torre, Miguel Ángel Martínez-González, Elena H Martínez-Lapiscina, Montserrat Fitó, Ana Pérez-Heras, Jordi Salas-Salvadó, Ramon Estruch, Emilio Ros, None, Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial JAMA Internal Medicine. ,vol. 175, pp. 1094- 1103 ,(2015) , 10.1001/JAMAINTERNMED.2015.1668
Shoujiao Peng, Baoxin Zhang, Juan Yao, Dongzhu Duan, Jianguo Fang, Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells Food & Function. ,vol. 6, pp. 2091- 2100 ,(2015) , 10.1039/C5FO00097A