Antiviral activity of a derivative of the photosensitive compound Hypericin
作者： L. Yip , J.B. Hudson , E. Gruszecka-Kowalik , L.H. Zalkow , G.H. Neil Towers
DOI: 10.1016/S0944-7113(96)80034-1
关键词: Derivative (chemistry) 、 Mechanism of action 、 Sindbis virus 、 Membrane protein 、 Hypericin 、 Singlet oxygen 、 Capsid 、 Poliovirus 、 Stereochemistry 、 Chemistry
摘要: Summary Eight synthetic compounds related to the photosensitive antiviral quinonic plant compound hypericin were screened for light-mediated activity. The 2,5,9,12-tetra(carboxyethylthiomethyl) was found have activity against membrane-enveloped Sindbis virus and murine cytomegalovirus but not non-enveloped poliovirus. of this investigated in more detail. mechanism action appeared be singlet oxygen type could reduced by presence a quencher molecule. membrane proteins altered treatment with or hypericin, although derivative did affect electrophoretic mobility capsid protein.
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